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During the past decade, efforts have been made to establish psychoactive substances increased in marijuana. The endocannabinoid system has been discovered, which affects the physiology of almost all systems of the body. Its most important role is the protection of the nervous system, but over the last decade it has been shown to be involved in other processes, including depression, anxiety, cancer progression, vasodilation of bone formation, and even pregnancy.

It is believed that cannabinoids (which occur in hemp, note) and endocannabinoids (which the organism naturally produces, note) are a healing treasure waiting to be discovered.


Raphael Mechoulam will tell you a story about the discovery of the endocannabinoid system. His research should not only help us to understand the application and effect of hemp, but it also makes a significant contribution when it comes to understanding "neuroprotection" (nerve protection, note). Thus, he opened the door for the development of new drugs.

The endocannabinoid system

In the year 1960, a component of the hemp plant, called tetrahydrocannabinol, was discovered, which causes "fogging". Thousands of publications have already been published on THC. Today, it is even used as a drug for nausea and appetite stimulation, which surprisingly did not turn into an illegal drug - obviously hemp consumers prefer the plant that makes marijuana and hashish.


Two decades later, THC was found to bind to specific receptors in the brain and its environment, and this interaction initiates a cascade of biological processes leading to the well-known state of marijuana. We have hypothesized that cannabinoid receptors exist not only for the needs of marijuana users, but rather for the putative endocannabinoid constituents in the brain, and that these "signal" molecules, along with the cannabinoid receptors, are part of a biochemical system, which can influence different physiological functions.


In an effort to identify these unknown putative signaling molecules, our research group successfully isolated two endogenous components in 1990. The first in the brain, called Anandamide (Ananda - Joy), and the second from the gut called 2-Arachidonoylglycerol (2-AG).

neuroprotection

The major endocannabinoid (2-AG) was detected in the central nervous system and its surroundings. For example, in mice after brain injury, their (2-AG) levels were increased in both the endocannabinoid and cannabinoid modes. The result was a higher protection against insufficient blood flow to tissue and organs (ischemia) and the death of nerve cells (excitotoxicity). 2 AG also helps to repair the hemato-encephalitic barrier to internal head injuries. This effect may come from the ability of cannabinoids to act by various biochemical mechanisms.


Endocannabinoids act through specific cannabinoid receptors, of which CB1 are the most common receptors in the central nervous system. In mice that have been switched off the CB1 receptors, the recovery after a traumatic brain injury is much slower and they do not respond to 2-AG treatment. In recent years, some research groups have noted that the CB2 receptors are also formed in the brain, especially in response to numerous neurological disorders, and they are apparently activated as a protective mechanism by endocannabinoids.


Similar to how the immune system evolved to protect against microbes during evolution, the lesser known endocannabinoid system has also developed for the purpose of protection. It restricts, for example, damage after brain trauma, reduces the extent of cerebral edema, and aids in renewal due to neurological injury.

Clinical significance

Furthermore, it is believed that the endocannabinoid system may be involved in the development of liver encephalopathy, a neuropsychiatric syndrome caused by very rapid liver failure. In animals, after the administration of 2-AG actually the neurological processes and the cognitive functions (perception and thinking, note) improved. The authors concluded that the endocannabinoid system may play an important role in the pathogenesis of liver encephalopathy.


The endocannabinoid system is involved in the protective mechanism of the body in mammals and thus plays an important protective role in a long list of diseases, such as the development of multiple sclerosis and Alzheimer's and Parkinson's disease, opening the way to new therapeutic options ,


Many other endocannabinoids - especially various ethanolamides of unsaturated fatty acids and glycerol compounds, which are now known and considered as members of the large "endocannabinoid family". Endogenous cannabinoids, cannabinoid receptors, and various enzymes involved in its assembly and reduction form the endocannabinoid system.


The endocannabinoid system thus behaves as a guardian from various attacks on the mammalian body.

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conclusion

The above-described study concerning the endocannabinoid system is important for both basic research and therapies:

• The discovery of the active ingredient in hemp helped to confess hemp application and its effects

• The discovery of endocannabinoids is very important for the development of new biochemical systems and their physiological roles - especially in neuroprotection.

• These discoveries opened the door to the discovery of new types of remedies, such as THC for the treatment of malaise and for the improvement of appetite in cachectic patients.

• The endocannabinoid system is involved in the defense reaction of mammalian bodies. It plays a very important protective role in a long list of diseases, such as the development of multiple sclerosis and Alzheimer's and Parkinson's disease, opening the door to new therapeutic options.

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