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Tourette's Syndrome Growmart

In Holland it is possible to obtain hemp in the pharmacy only on the basis of a few accepted indicators on prescription. These include not only chronic pain but also the spastic paralysis of multiple sclerosis, and from other diseases such as this Tourette syndrome. The disease was named after Dr. Gilles de la Tourette, the doctor who first described this syndrome.

Tourette syndrome is a complex neuropsychiatric disorder that usually manifests during childhood or adulthood. With him are so-called "Ticks" typical, sudden twitching especially in the area of ​​the face, neck and shoulders (warping of the mouth, twitching head turning). Accompanying occurs at least one more vocal tick, in which the person makes loud noises or exclaims different curses. Another concomitant effect is behavioral disorders, such as aggression against oneself, hypersexuality or compulsive thoughts or behaviors.

The majority of the facts known today regarding the effect of THC and hemp on this very difficult to cure disease are based on clinical tests in Germany. At the medical school in Hannover, a team of Professor Kirsten Müller-Vahl conducted a study on the effect of THC on Tourette's syndrome. Some patients who were treated in the special outpatient clinic stated that they had a decline in the symptoms of illness due to the use of hemp. A systematic 1994 1996 survey of 64 14 patients in 17 patients showed that XNUMX patients with experience in hemp use had a positive impact on the symptoms of the disease, sometimes leading to a complete disappearance of motor and vocal ticks. Similar conclusions from other authors have occasionally appeared in specialist journals in the past.

During the first examination at Hannover Medical School, each patient received a single 10 mg THC, which significantly improved his symptoms. At the second observation, some patients once received five to ten milligrams of THC. As a result both tics and compulsive symptoms became less. Mood, mental performance and concentration were not influenced to any significant extent by this dose of dronabinol.

 

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In a third study, 17 patients were evaluated for the effects and tolerability of THC in a placebo comparison for a period of six weeks. Originally, 24 patients participated in the study, with 12 patients always taking either THC in capsules or a visually and taste identical placebo. Seven patients discontinued the study prematurely or were excluded from the evaluation because they did not meet the agreed conditions of the study. For example, one patient took one drug while another had a negative THC urine test, although this should have been positive. Only one patient discontinued the study due to excessive side effects (approx. 24 hours of constipation). For the final evaluation, eight patients remained in the THC group and ten patients in the placebo group. Administration was continued at a rate of 2,5 milligrams daily, always for breakfast or lunch, which was then increased to a maximum dose of ten milligrams daily, depending on tolerability at three-day intervals.

It measured the intensity of Tourette's symptoms and psychomotor performance, as well as a few other parameters. Investigators never knew if it was a patient taking THC or placebo. Symptoms of dronabinol-treated patients have improved significantly compared to placebo-treated patients. The improvement was on the 30. or 31. Day of study greater than on 21. or 22. Day. This fact can serve as evidence that the effect of THC increased during the study.

If we summarize, THC and hemp appear to have beneficial effects on Tourette's syndrome, despite the fact that to date only one convincing study has been available with patients suffering from Tourette syndrome. The therapeutic effect is so clear in some of the patients that the symptoms of this severely limiting neuropsychiatric disease completely or almost completely disappear. In general, the treatment requires only a relatively low dose, which in most patients does not even lead to any relevant side effects.

Dr. med. Franjo Grotenhermen

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